|(S)-2-(二甲基氨基甲硫酰基)-N-(2-甲基-4-(1-甲基-1,4,5,10-四氢苯并[b]吡唑并[3,4-e][1,4]二氮杂卓-5-羰基)苄基)吡咯烷-1-甲酰胺 2,2,2-三氟乙酸盐|CsnPharm

CAS No.: 2245072-21-1

Synonyms: LIT-001 TFAsalt

LIT-001 is the first nonpeptide oxytocin receptor agonist.

规格	价格	促销价格	库存	数量

400-920-2911

加入购物车大规格询价

产品咨询

400-920-2911

纯度 & 质量文件批次:

生物活性

描述LIT-001 is the first nonpeptide oxytocin receptor agonist with EC50 values of 25nM, 18nM and 41nM for calcium release on hOTR, mOTR and V₂R, and 62nM and 660nM for β-arrestin recruitment on OTR and V₂R. It could efficiently relieved social interaction deficits in autism model Oprm1^−/− mice. Compared with oxytocin which is known as poorly brain penetrant, LIT-001 possesses brain penetrance and bioavailability. Administration of LIT-001 at dose of 10mg/kg, i.p., normalized the number and duration of nose contacts, the frequency of following episodes and the occurrence of grooming episodes after a social contact of this autism model to wild-type levels.

实验方案

技术信息

CAS号	2245072-21-1	储存条件	粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C30H34F3N7O4S	运输	蓝冰
分子量	645.69	别名	LIT-001 TFAsalt

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

请登录您的专属账户